Морфологические изменения в тканях периодонта лабораторных животных при применении мезенхимальных стволовых клеток
В статье приведены результаты исследования морфологических изменений в тканях периодонта лабораторных животных при использовании мезенхимальных стволовых клеток (МСК). Цель исследования – разработать модель экспериментального периодонтита и установить характер морфологических изменений в тканях периодонта при применении биомедицинского клеточного продукта на основе аллогенных МСК жировой ткани (МСК ЖТ). Применение смеси МСК ЖТ и остеоиндуцированных МСК ЖТ в пропорции 1:1 позволяет сократить сроки регенерации костного дефекта по сравнению c длительностью восстановления костной ткани при применении МСК ЖТ, а также остеоиндуцированных МСК ЖТ, что выражается в заполнении дефекта костной ткани наряду с мышечной фиброретикулярной остеогенной тканью через 1 мес. после оперативного вмешательства. Через 2 мес. в зоне дефекта, заполненного коллагеновой мембраной со смесью МСК ЖТ и остеоиндуцированных МСК ЖТ, выявлены признаки начала формирования костных балок, что свидетельствует о более полноценном остеосинтезе, чем при заживлении под кровяным сгустком.
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